Out-of-hospital ECPR favorable CPC calculator

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Estimates the probability of survival to hospital discharge with a favorable neurologic outcome (Cerebral Performance Category [CPC] 1–2) in adults with out-of-hospital cardiac arrest supported with extracorporeal cardiopulmonary resuscitation (ECPR).

Complete all 10 fields using information available at cannulation. Do not enter an unknown value as zero or “No.”

Age (years) Location of cardiac arrest Initial cardiac arrest rhythm Number of defibrillation shocks

ROSC before cannulation

Multiple cardiac arrests

Signs of life prior to cannulation

Total CPR duration (minutes)

Pulse at cannulation

Rhythm at time of cannulation

Predicted probability of survival with a favorable CPC (CPC 1-2)

Research and education only. Independent external validation is required before clinical use. This estimates prognosis among ECPR recipients, not the benefit of ECPR or whether treatment should be withheld.

About this calculator

Outcome definition (CPC).
The Cerebral Performance Category (CPC) scale is a commonly used measure of neurologic outcome following cardiac arrest. CPC ranges from 1 to 5, where CPC 1 indicates good cerebral performance, CPC 2 moderate disability but independent function, CPC 3 severe disability, CPC 4 vegetative state, and CPC 5 death. In this calculator, a favorable neurologic outcome is defined as survival to hospital discharge with a CPC of 1-2.

Model development.
This calculator was developed using data from adult patients supported with extracorporeal cardiopulmonary resuscitation (ECPR). These data were derived from the Extracorporeal Life Support Organization (ELSO) patient registry, which maintains a comprehensive registry of patients undergoing extracorporeal life support at centers worldwide.

Authors.
Ahmad A. Abdul-Aziz, MD
Abhimanyu Chandel, MD MAS
Adam Green, MD MBA
Chase Donaldson, MD
Nitin Puri, MD
Steven A. Conrad, MD PhD
Christopher S. King, MD

Intended use.
This tool is intended to support clinical discussion, risk stratification, and shared decision-making. It is not intended to be used in isolation to determine candidacy for ECPR or decisions about life-sustaining therapy.

A link to the associated manuscript will be added here when it becomes available.

This calculator is provided for research and educational purposes only and has not been approved as a medical device. Use does not replace expert clinical assessment.

Last updated: September 21, 2026